| Name: | Dulaglutide |
|---|---|
| Item Code: | HG044 |
| CAS Number: | 923950-08-7 |
| Other name: | Dulaglutide |
| Molecular formula: | C149H221N37O49 |
| Molecular mass: | 3314.62 |
| Sequence: | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile- Ala-Trp-Leu-Val-Lys-Gly-Gly-Gly-OH |
| Purity: | ＞95% |
| Main usage: | For research only, not for human |
Dulaglutide is a new long-acting GLP-1R agonist. It is obtained by fusion of two GLP-1 analogs with DPP-4 inhibitory effect and human immunoglobulin heavy chain IgG4-Fc fragment. Its activity is comparable to that in clinical manifestations. Endogenous GLP-1 is similar, with a half-life of 5 days, which can effectively delay the clearance of the kidneys. The FDA approved the marketing of dulaglutide subcutaneous injection in September 2014. The European Commission approved dulaglutide subcutaneous injection in Europe in December 2014.
【Test】 | 【Specifications】 |
Appearance | White to off-white powder |
Molecular Ion Mass | 3314.62±1 |
Purity (HPLC) : | NLT 95.0% |
Related Substances(HPLC) | Total impurities: <5.0% Single impurity: <2.0% |
Acetic acid (HPLC) | 5% ~ 12% |
Water Content(Karl Fischer) : | ≦ 10.0 % |
Peptide Content : | NLT 80% |
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