Name: | Nesiritide Acetate |
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Item Code: | HG058 |
CAS Number: | 114471-18-0 |
Other name: | Nesiritide Acetate |
Molecular formula: | C143H244N50O42S4 |
Molecular mass: | 3464.04 |
Sequence: | H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly- Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge Cys10-Cys26) |
Purity: | >98% |
Main usage: | For research only, not for human |
Product Description
Nesiritide is a polypeptide containing 32 amino acids. The first synthetic human brain natriuretic peptide (BNP) obtained from Escherichia coli (Escherichia coli) using recombinant DNA technology is very similar to human BNP. The 10th and 26th amino acids (both cysteine) in Nesiritide are connected by a disulfide bond to form a ring structure containing 17 amino acids, so the stability of Nesiritide is better, and It has a long half-life in the organism. Studies have shown that drugs with artificially synthesized Nesiritide as the main raw material have clear curative effects in the treatment of heart failure, especially acute heart failure.
【Test】 | 【Specifications】 |
Appearance | White to off-white powder |
Molecular Ion Mass | 3464.04±1 |
Purity (HPLC) : | NLT 98.0% |
Related Substances(HPLC) | Total impurities: <2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | 5% ~ 12% |
Water Content(Karl Fischer) : | ≦ 8.0 % |
Peptide Content : | NLT 80% |