| Name: | Leuprolide |
|---|---|
| Item Code: | HG021 |
| CAS Number: | 74381-53-6 |
| Other name: | Leuprolide |
| Molecular formula: | C59H84N16O12 |
| Molecular mass: | 1209.5 |
| Sequence: | Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt |
| Purity: | ＞98% |
| Main usage: | Advanced hormone-dependent prostate cancer, Advanced hormone-dependent breast cancer, Endometriosis, Uterine myoma,Central precocious puberty |
Leuprolide Acetate is a potent LHRH (GnRH) agonist. After a transient increase, continuous administration of leuprolide results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis. Studies with female Alzheimer patients indicate that application of leuprolide acetate in combination with an acetylcholinesterase inhibitor stabilizes the cognitive functions in mild-to-moderate cases.
【Test】 | 【Specifications】 |
Appearance | White to off-white powder |
Solubility | Soluble in water and 1% (V/V) aqueousacetic acid at a concentration of ≥ 10mg/mL to give a clear solution |
Molecular Ion Mass | 1209.4±1 |
Specific Optical Rotation | -38.0~-42.0 º (c=1，1%HAc) |
Amino Acid Analysis | ±20% of theore |
Purity (HPLC) : | NLT 98.0% |
Related Substances(HPLC) | Total impurities:<2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | 5.0～9.0% |
Water Content(Karl Fischer) : | ≦8.0 % |
Peptide Content : | NLT 80% |
Bacterial Endotoxins : | ≦5 IU/mg |
Assay(Anhydrous and acetic acid-free substance) | 97.0～103.0％ |
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