| Name: | Terlipressin |
|---|---|
| Item Code: | HG030 |
| CAS Number: | 14636-12-5 |
| Other name: | Terlipressin |
| Molecular formula: | C52H74N16O15S2 |
| Molecular mass: | 1227.39 |
| Sequence: | H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Disulfide bond) |
| Purity: | ＞98% |
| Main usage: | Acute variceal hemorrhage (esophageal varices), Hepatorenal syndrome, Norepinephrine-resistant septic shock - not yet an approved application |
Terlipressin is a synthetic analog of vasopressin and is used as a vasoactive drug in the management of hypotension.
Terlipressin represents a prodrug, it is converted to (Lys8)- vasopressin (LVP) after removal of the N-terminal triglycine in vivo. Terlipressin has a longer duration of action and a better safety profile than the parent compound L
【Test】 | 【Specifications】 |
Appearance | White powder |
Solubility | Very soluble in water (>1mg/ml) |
Identification By HPLC | Retention time is same with the reference substance |
Molecular Ion Mass | 1227.39±1 |
Amino Acid Composition | ±10% |
Purity (HPLC) : | NLT 98.0 % |
Related Substances(HPLC) | Total impurities <2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | ≦12.0 % |
Water Content(Karl Fischer) : | ≦8 % |
Peptide Content : | NLT 80% |
Residual Solvents(Acetonitrile) | ≦0.05% |
Assay(By Anhydrous, Acetic Acid-free) | 95.0～105.0％ |
Bacterial Endotoxins : | ≦5EU/mg |
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