Name: | Gonadorelin |
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Item Code: | HV005 |
CAS Number: | 34973-08-5 |
Other name: | Gonadorelin |
Molecular formula: | C55H75N17O13 |
Molecular mass: | 1182.31 |
Sequence: | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
Purity: | >98% |
Main usage: | Ovarian follicular cysts (veterinary medicine), Use in reproduction medicine, Diagnosis of the hypothalamic-pituitary-gonadal axis function, Cryptorchism, Synchronization of ovulation (veterinary medicine) |
Product Description
Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
【Test】 | 【Specifications】 |
Appearance | White to off-White powder |
Solubility | Soluble in water at a concentration of 10 mg/mL to give a clear solution not more intensely colored than reference solution Y5 |
Light absorption (278 nm, 0.1 mg/mL in water) | 0.55 to 0.61 (corrected for peptide content) |
Identification , TLC | Corresponds to reference standard |
Molecular Ion Mass | 1182.3±1 |
Specific optical rotation (c = 1.0, 1% acetic acid) | -54 to -66 |
Amino Acid Composition | Ser: 0.7 to 1.05 Glx: 0.95 to 1.05 Pro: 0.95 to 1.05 Gly: 1.9 to 2.1 Leu: 0.9 to 1.1 Tyr: 0.7 to 1.05 His: 0.95 to 1.05 Arg: 0.95 to 1.05 Trp: Present |
Purity (HPLC) : | NLT 98.0 % |
Related Substances(HPLC) | Total impurities <2.0% Single impurity: <1.0% |
Acetic acid (HPLC) | 8.0 % to 12.5% |
Water Content(Karl Fischer) : | ≦7 % |
Trifluoroacetic acid | ≦0.25% |
Residual Solvents(Acetonitrile) | ≦0.041% |
Assay Mass balance | 95.0~102.0% |
Bacterial Endotoxins : | ≦70IU/mg |